Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

Yael Cohen-Sharir; Uri Ben-David

doi:10.1080/23723556.2021.1915075

Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

Yael Cohen-Sharir, Uri Ben-David^*

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs targeting SAC core members and KIF18A. We stress the need to assess the sensitivity to this class of drugs at appropriate time points, and propose that aneuploidy could serve as a biomarker to stratify patients for SAC-targeting treatments.

Original language	English
Article number	1915075
Journal	Molecular and Cellular Oncology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2021.1915075
State	Published - 2021

Keywords

Aneuploidy
KIF18A
SAC
cancer
cancer therapies
spindle assembly checkpoint

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/23723556.2021.1915075

Cite this

@article{0929b51f48aa4d1bb01f19dd31c60714,

title = "Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A",

abstract = "Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs targeting SAC core members and KIF18A. We stress the need to assess the sensitivity to this class of drugs at appropriate time points, and propose that aneuploidy could serve as a biomarker to stratify patients for SAC-targeting treatments.",

keywords = "Aneuploidy, KIF18A, SAC, cancer, cancer therapies, spindle assembly checkpoint",

author = "Yael Cohen-Sharir and Uri Ben-David",

note = "Publisher Copyright: {\textcopyright} 2021 Taylor & Francis Group, LLC.",

year = "2021",

doi = "10.1080/23723556.2021.1915075",

language = "אנגלית",

volume = "8",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

AU - Cohen-Sharir, Yael

AU - Ben-David, Uri

PY - 2021

Y1 - 2021

N2 - Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs targeting SAC core members and KIF18A. We stress the need to assess the sensitivity to this class of drugs at appropriate time points, and propose that aneuploidy could serve as a biomarker to stratify patients for SAC-targeting treatments.

AB - Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs targeting SAC core members and KIF18A. We stress the need to assess the sensitivity to this class of drugs at appropriate time points, and propose that aneuploidy could serve as a biomarker to stratify patients for SAC-targeting treatments.

KW - Aneuploidy

KW - KIF18A

KW - SAC

KW - cancer

KW - cancer therapies

KW - spindle assembly checkpoint

UR - http://www.scopus.com/inward/record.url?scp=85105150981&partnerID=8YFLogxK

U2 - 10.1080/23723556.2021.1915075

DO - 10.1080/23723556.2021.1915075

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 34027049

AN - SCOPUS:85105150981

SN - 2372-3556

VL - 8

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - 1915075

ER -

Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this