Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients

G. Zalsman*, G. M. Anderson, M. Peskin, A. Frisch, R. A. King, M. Vekslerchik, E. Sommerfeld, E. Michaelovsky, L. Sher, Avraham Weizman, Alan Apter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Relationships between the serotonin transporter promoter polymorphism (5-HTTLPR), platelet serotonin transporter (SERT) binding and clinical phenotype were examined in 32 suicidal and 28 non-suicidal Ashkenazi Israeli adolescent psychiatric inpatients. The 5-HTTLPR polymorphism was not associated with transporter binding or with suicidality or other clinical phenotypes. However, in the suicidal group, a significant positive correlation between platelet SERT density and anger scores (n = 32, r = .40; p = .027) and a negative correlation between platelet count and trait anxiety (n = 32, r = -.42; p = .034) were observed.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalJournal of Neural Transmission
Volume112
Issue number2
DOIs
StatePublished - Feb 2005

Keywords

  • 5-HTTLPR
  • Adolescent
  • Endophenotype
  • Serotonin
  • Serotonin transporter
  • Suicide

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