Relationship of platelet MAO activity to characteristics of major depressive illness

Anastasios Georgotas, Robert E. McCue, Eitan Friedman, William E. Hapworth, O. Mary Kim, Thomas B. Cooper, Irene Chang, Peter E. Stokes

Research output: Contribution to journalArticlepeer-review


Sixty-seven patients (≥55 years of age) with major depressive disorder had pretreatment assays of platelet monoamine oxidase (MAO) activity. As in previous studies, women had higher MAO activity than men, and MAO activity was positively correlated with age. Patients with melancholia (DSM-III) had significantly higher MAO activity than those without melancholia. This finding may reflect the higher MAO activity associated with the symptoms of anhedonia and mood autonomy. Anxiety also was correlated with higher MAO activity, as was a positive family history of depression. In addition, postdexamethasone cortisol levels were correlated with platelet MAO activity.

Original languageEnglish
Pages (from-to)247-256
Number of pages10
JournalPsychiatry Research
Issue number4
StatePublished - Dec 1986
Externally publishedYes


  • depression
  • dexamethasone suppression test
  • melancholia
  • Platelet monoamine oxidase activity
  • subtypes of depression


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