Relationship of platelet MAO activity to characteristics of major depressive illness

Anastasios Georgotas; Robert E. McCue; Eitan Friedman; William E. Hapworth; O. Mary Kim; Thomas B. Cooper; Irene Chang; Peter E. Stokes

doi:10.1016/0165-1781(86)90118-6

Relationship of platelet MAO activity to characteristics of major depressive illness

Anastasios Georgotas, Robert E. McCue, Eitan Friedman, William E. Hapworth, O. Mary Kim, Thomas B. Cooper, Irene Chang, Peter E. Stokes

Research output: Contribution to journal › Article › peer-review

Abstract

Sixty-seven patients (≥55 years of age) with major depressive disorder had pretreatment assays of platelet monoamine oxidase (MAO) activity. As in previous studies, women had higher MAO activity than men, and MAO activity was positively correlated with age. Patients with melancholia (DSM-III) had significantly higher MAO activity than those without melancholia. This finding may reflect the higher MAO activity associated with the symptoms of anhedonia and mood autonomy. Anxiety also was correlated with higher MAO activity, as was a positive family history of depression. In addition, postdexamethasone cortisol levels were correlated with platelet MAO activity.

Original language	English
Pages (from-to)	247-256
Number of pages	10
Journal	Psychiatry Research
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0165-1781(86)90118-6
State	Published - Dec 1986
Externally published	Yes

Keywords

depression
dexamethasone suppression test
melancholia
Platelet monoamine oxidase activity
subtypes of depression

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10.1016/0165-1781(86)90118-6

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title = "Relationship of platelet MAO activity to characteristics of major depressive illness",

abstract = "Sixty-seven patients (≥55 years of age) with major depressive disorder had pretreatment assays of platelet monoamine oxidase (MAO) activity. As in previous studies, women had higher MAO activity than men, and MAO activity was positively correlated with age. Patients with melancholia (DSM-III) had significantly higher MAO activity than those without melancholia. This finding may reflect the higher MAO activity associated with the symptoms of anhedonia and mood autonomy. Anxiety also was correlated with higher MAO activity, as was a positive family history of depression. In addition, postdexamethasone cortisol levels were correlated with platelet MAO activity.",

keywords = "depression, dexamethasone suppression test, melancholia, Platelet monoamine oxidase activity, subtypes of depression",

author = "Anastasios Georgotas and McCue, {Robert E.} and Eitan Friedman and Hapworth, {William E.} and Kim, {O. Mary} and Cooper, {Thomas B.} and Irene Chang and Stokes, {Peter E.}",

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AU - Georgotas, Anastasios

AU - McCue, Robert E.

AU - Friedman, Eitan

AU - Hapworth, William E.

AU - Kim, O. Mary

AU - Cooper, Thomas B.

AU - Chang, Irene

AU - Stokes, Peter E.

PY - 1986/12

Y1 - 1986/12

N2 - Sixty-seven patients (≥55 years of age) with major depressive disorder had pretreatment assays of platelet monoamine oxidase (MAO) activity. As in previous studies, women had higher MAO activity than men, and MAO activity was positively correlated with age. Patients with melancholia (DSM-III) had significantly higher MAO activity than those without melancholia. This finding may reflect the higher MAO activity associated with the symptoms of anhedonia and mood autonomy. Anxiety also was correlated with higher MAO activity, as was a positive family history of depression. In addition, postdexamethasone cortisol levels were correlated with platelet MAO activity.

AB - Sixty-seven patients (≥55 years of age) with major depressive disorder had pretreatment assays of platelet monoamine oxidase (MAO) activity. As in previous studies, women had higher MAO activity than men, and MAO activity was positively correlated with age. Patients with melancholia (DSM-III) had significantly higher MAO activity than those without melancholia. This finding may reflect the higher MAO activity associated with the symptoms of anhedonia and mood autonomy. Anxiety also was correlated with higher MAO activity, as was a positive family history of depression. In addition, postdexamethasone cortisol levels were correlated with platelet MAO activity.

KW - depression

KW - dexamethasone suppression test

KW - melancholia

KW - Platelet monoamine oxidase activity

KW - subtypes of depression

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Relationship of platelet MAO activity to characteristics of major depressive illness

Abstract

Keywords

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