Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus

Sharon Baum*, Itai Atar, Dan Coster, Sara Dovrat, Michal Solomon, Eli Sprecher, Tal Zeeli, Aviv Barzilai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Pemphigus vulgaris is a rare autoimmune skin dis-ease. Although herpes simplex virus has been associated with autoimmune diseases, evidence regarding its association with pemphigus vulgaris exacerbations is scarce. This retrospective cohort study aimed to characterize the epidemiological and clinical features of patients with pemphigus vulgaris who were herpes simplex-positive, compared with those who were herpes simplex-negative, during disease onset. Of 62 patients with pemphigus vulgaris who underwent PCR testing for herpes simplex virus, 25 (40.3%) were positive, with a mean age of 56.1 ± 15.5 years; 35.5% were male. The herpes-positive group had significantly elevated levels of C-reactive protein, Pemphigus Disease Activity Index score, and shorter time to re-lapse. The time to remission, number of exacerbations per year, and remission status were non-significantly elevated in the herpes-positive group. Thus, routine testing lesions from patients with pemphigus for herpes simplex virus should be performed. If positive, antiviral treatment should be initiated; and preven-tive antiviral treatment should be considered in severe cases.

Original languageEnglish
Article numberadv00703
Number of pages6
JournalActa Dermato-Venereologica
StatePublished - 2022


FundersFunder number
Edmond J. Safra Center
Tel Aviv University


    • acyclovir
    • disease exa-cerbation
    • herpes simplex
    • pemphigus vulgaris


    Dive into the research topics of 'Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus'. Together they form a unique fingerprint.

    Cite this