Relationship between changes in thyroid hormone level and severity of the postoperative course in neonates undergoing open-heart surgery

Ovadia Dagan, Bernardo Vidne, Zeev Josefsberg, Moshe Phillip, David Strich, Eldad Erez

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Our aim was to determine whether the changes in thyroid function after open-heart surgery in neonates depend on the postoperative course. Methods: Twenty neonates undergoing open-heart surgery for congenital heart disease were prospectively studied in the cardiac intensive care unit of a university-affiliated children's hospital. The patients were divided into two groups by level of inotropic support (high or mild). Results: The groups were similar in age, bypass time and ultrafiltration volume. In both groups, there was a significant reduction in levels of thyroid-stimulating hormone and FT4 at 24 h postoperatively. However, in the high inotropic support group, FT4 was lower for a longer time. This group also had a significantly higher score on The Pediatric Risk of Mortality (PRISM; P < 0.042) and a longer duration of ventilation (P < 0.014). Conclusions: Neonates after open-heart surgery undergo changes in thyroid function characteristic of euthyroid sick syndrome. The degree of hypothyroxinemia may be related to the severity of illness and the postoperative course.

Original languageEnglish
Pages (from-to)538-542
Number of pages5
JournalPaediatric Anaesthesia
Volume16
Issue number5
DOIs
StatePublished - May 2006

Keywords

  • Eruthyroid sick syndrome
  • Inotropic support
  • Neonate
  • Open-heart surgery

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