TY - JOUR
T1 - Relationship between antidepressants and IGF-1 system in the brain
T2 - Possible role in cognition
AU - Grunbaum-Novak, Nurit
AU - Taler, Michal
AU - Gil-Ad, Irit
AU - Weizman, Abraham
AU - Cohen, Hagit
AU - Weizman, Ronit
N1 - Funding Information:
Funding for this study was provided by the National Institute for Psychobiology Grant No. 200719; the National Institute for Psychobiology had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2008/6
Y1 - 2008/6
N2 - Antidepressants facilitate neuroplasticity by stimulating trophic factors. This study evaluated the effect of fluoxetine (FLX) treatment on insulin-like growth factor-1 (IGF-1) in the rat brain and its role in the effect of FLX on cognition. IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats. Rats were subjected to the Morris Water Maze test. Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC. Repeated FLX increased both mRNA and IGF-1R levels in the FC. Repeated, but not acute, FLX treatment decreased IGF-1 mRNA in the hippocampus. FLX did not affect cognitive performance. Thus, repeated FLX treatment leads to upregulation of IGF-1 system is FC. It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system.
AB - Antidepressants facilitate neuroplasticity by stimulating trophic factors. This study evaluated the effect of fluoxetine (FLX) treatment on insulin-like growth factor-1 (IGF-1) in the rat brain and its role in the effect of FLX on cognition. IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats. Rats were subjected to the Morris Water Maze test. Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC. Repeated FLX increased both mRNA and IGF-1R levels in the FC. Repeated, but not acute, FLX treatment decreased IGF-1 mRNA in the hippocampus. FLX did not affect cognitive performance. Thus, repeated FLX treatment leads to upregulation of IGF-1 system is FC. It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system.
KW - Antidepressants
KW - Cognition
KW - Fluoxetine
KW - Frontal Cortex
KW - Hippocampus
KW - IGF-1
UR - http://www.scopus.com/inward/record.url?scp=42949094583&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2007.08.004
DO - 10.1016/j.euroneuro.2007.08.004
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AN - SCOPUS:42949094583
SN - 0924-977X
VL - 18
SP - 431
EP - 438
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 6
ER -