Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma

Elad Jacoby, Michal Yalon, Moshe Leitner, Zvi R. Cohen, Yehudit Cohen, Tamar Fisher, Sarit Eder, Ninette Amariglio, Gideon Rechavi, Simona Cazacu, Cunli Xiang, Tom Mikkelsen, Chaya Brodie, Amos Toren

Research output: Contribution to journalArticlepeer-review

Abstract

Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.

Original languageEnglish
Pages (from-to)1209-1212
Number of pages4
JournalOncology Letters
Volume7
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Glioblastoma
  • Glioma pathogenesis-related protein 1
  • Methylation
  • Related to testes-specific vespid and pathogenesis protein-1

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