Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma

Elad Jacoby*, Michal Yalon, Moshe Leitner, Zvi R. Cohen, Yehudit Cohen, Tamar Fisher, Sarit Eder, Ninette Amariglio, Gideon Rechavi, Simona Cazacu, Cunli Xiang, Tom Mikkelsen, Chaya Brodie, Amos Toren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.

Original languageEnglish
Pages (from-to)1209-1212
Number of pages4
JournalOncology Letters
Volume7
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Glioblastoma
  • Glioma pathogenesis-related protein 1
  • Methylation
  • Related to testes-specific vespid and pathogenesis protein-1

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