TY - JOUR
T1 - Relapse of aggressive myeloma after complete remission in secondary acute leukemia
T2 - Coincidence or consequence?
AU - Bairey, Osnat S.
AU - Shaklai, Matityahu
AU - Sandbank, Yehudith
PY - 1993
Y1 - 1993
N2 - We describe a patient with multiple myeloma who developed secondary acute myelomonocytic leukemia after long-term melphalan treatment. Following two courses of low-dose cytarabine, complete remission of the A.M.L. was achieved. Shortly thereafter an aggressive relapse of the quiescent myeloma occurred with acute renal failure and massive infiltration of bone marrow with multinucleated giant plasma cells. Although it is well known that administration of melphalan to patients with multiple myeloma increases the likelihood of A.M.L., this case demonstrates that treatment of A.M.L. in a patient with multiple myeloma may perhaps influence the course of multiple myeloma.
AB - We describe a patient with multiple myeloma who developed secondary acute myelomonocytic leukemia after long-term melphalan treatment. Following two courses of low-dose cytarabine, complete remission of the A.M.L. was achieved. Shortly thereafter an aggressive relapse of the quiescent myeloma occurred with acute renal failure and massive infiltration of bone marrow with multinucleated giant plasma cells. Although it is well known that administration of melphalan to patients with multiple myeloma increases the likelihood of A.M.L., this case demonstrates that treatment of A.M.L. in a patient with multiple myeloma may perhaps influence the course of multiple myeloma.
KW - Multiple myeloma
KW - Secondary acute leukemia
UR - http://www.scopus.com/inward/record.url?scp=0027716682&partnerID=8YFLogxK
U2 - 10.3109/10428199309059584
DO - 10.3109/10428199309059584
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C2 - 8161931
AN - SCOPUS:0027716682
SN - 1042-8194
VL - 12
SP - 147
EP - 151
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1-2
ER -
