TY - CHAP
T1 - Regulatory T-Cells, FoxP3 and atherosclerosis
AU - Entin-Meer, Michal
AU - Afek, Arnon
AU - George, Jacob
PY - 2009
Y1 - 2009
N2 - Innate immune responses follow accumulation of modified lipids within the arterial wall thereby influencing atherosclerotic plaque progression. One of the mechanisms evolved in maintaining immunologic self-tolerance involves upregulation of regulatory Tvcells, among which the CD4+CD25+ FoxPY regulatory T-cells (Treg) are best characterized. The putative important role of Treg in the initiation of atherosclerotic lesions as well as in the progression towards unstable plaques leading to ischemic events, supported by human studies and, indirectly, by murine models. Herein, we summarize the experimental approaches taken in order to study the possible mechanisms ofTreg involvement in atherosclerosis as well as the beneficial clinical potential ofTreg in stabilizing atherosclerotic plaques.
AB - Innate immune responses follow accumulation of modified lipids within the arterial wall thereby influencing atherosclerotic plaque progression. One of the mechanisms evolved in maintaining immunologic self-tolerance involves upregulation of regulatory Tvcells, among which the CD4+CD25+ FoxPY regulatory T-cells (Treg) are best characterized. The putative important role of Treg in the initiation of atherosclerotic lesions as well as in the progression towards unstable plaques leading to ischemic events, supported by human studies and, indirectly, by murine models. Herein, we summarize the experimental approaches taken in order to study the possible mechanisms ofTreg involvement in atherosclerosis as well as the beneficial clinical potential ofTreg in stabilizing atherosclerotic plaques.
UR - http://www.scopus.com/inward/record.url?scp=77952467955&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-1599-3_8
DO - 10.1007/978-1-4419-1599-3_8
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C2 - 20429419
AN - SCOPUS:77952467955
SN - 9781441915986
T3 - Advances in Experimental Medicine and Biology
SP - 106
EP - 114
BT - Forkhead Transcription Factors
PB - Springer New York LLC
ER -