Regulatory T-Cells, FoxP3 and atherosclerosis

Michal Entin-Meer, Arnon Afek, Jacob George*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Innate immune responses follow accumulation of modified lipids within the arterial wall thereby influencing atherosclerotic plaque progression. One of the mechanisms evolved in maintaining immunologic self-tolerance involves upregulation of regulatory Tvcells, among which the CD4+CD25+ FoxPY regulatory T-cells (Treg) are best characterized. The putative important role of Treg in the initiation of atherosclerotic lesions as well as in the progression towards unstable plaques leading to ischemic events, supported by human studies and, indirectly, by murine models. Herein, we summarize the experimental approaches taken in order to study the possible mechanisms ofTreg involvement in atherosclerosis as well as the beneficial clinical potential ofTreg in stabilizing atherosclerotic plaques.

Original languageEnglish
Title of host publicationForkhead Transcription Factors
Subtitle of host publicationVital Elements in Biology and Medicine
PublisherSpringer New York LLC
Number of pages9
ISBN (Print)9781441915986
StatePublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


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