Regulatory T cell activity specific to human type II and III collagens in rheumatoid arthritis

O. Elkayam, H. Zinger, E. Zisman, R. Segal, M. Yaron, C. Brautbar, E. Mozes

Research output: Contribution to journalArticlepeer-review


Fifty-one patients with rheumatoid arthritis (RA) were examined for their immune response potential to human collagen type II and III. It was found that T cells of 57% of patients with RA proliferated to collagen type III whereas only 27% of T cells of patients with osteoarthritis (OA) and healthy controls responded to this antigen by proliferation (p<0.04). A lower percentage (38%) of patients with RA had proliferative responses to collagen type II in comparison to 17% of responders in healthy controls. The capability to produce T cell helper factors specific to collagen type III was found to be significantly higher in patients treated with nonsteroidal antiinflammatory drugs (NSAID) (60%) in comparison to patients with OA (16%) and healthy controls (13%). Immunoregulatory drugs affected the specific T helper function in response to collagen type III but did not change the proliferative responses to collagen type II and III in patients with RA. HLA analyses revealed a significant difference in the frequency of HLA-DRw10 between our sample of patients with RA and healthy controls.

Original languageEnglish
Pages (from-to)516-521
Number of pages6
JournalJournal of Rheumatology
Issue number4
StatePublished - 1991
Externally publishedYes


  • Collagen
  • Rheumatoid arthritis
  • T cell proliferation
  • T helper activity


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