TY - JOUR
T1 - Regulatory mutants of Streptomyces clavuligerus affected in free diaminopimelic acid content and antibiotic biosynthesis
AU - Aharonowitz, Y.
AU - Mendelovitz, S.
AU - Kirenberg, F.
AU - Kuper, V.
PY - 1984
Y1 - 1984
N2 - The composition of intracellular free amino acid pools was determined in Streptomyces clavuligerus mutants possessing an altered aspartokinase which is insensitive to concerted feedback inhibition by threonine and lysine. These mutants contained total free amino acid pool contents that were considerably higher than those found in the wild-type strain. Diaminopimelic acid accounted for 10 to 20% of the total free amino acid pools, depending on the individual mutant and its culture growth phase, whereas diaminopimelic acid contained in the wild-type strain accounted for only 0.5% of the total free amino acid pool.
AB - The composition of intracellular free amino acid pools was determined in Streptomyces clavuligerus mutants possessing an altered aspartokinase which is insensitive to concerted feedback inhibition by threonine and lysine. These mutants contained total free amino acid pool contents that were considerably higher than those found in the wild-type strain. Diaminopimelic acid accounted for 10 to 20% of the total free amino acid pools, depending on the individual mutant and its culture growth phase, whereas diaminopimelic acid contained in the wild-type strain accounted for only 0.5% of the total free amino acid pool.
UR - http://www.scopus.com/inward/record.url?scp=0021353775&partnerID=8YFLogxK
U2 - 10.1128/jb.157.1.337-340.1984
DO - 10.1128/jb.157.1.337-340.1984
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AN - SCOPUS:0021353775
SN - 0021-9193
VL - 157
SP - 337
EP - 340
JO - Journal of Bacteriology
JF - Journal of Bacteriology
IS - 1
ER -