Regulatory effect of hydrocortisone on the in vitro synthesis of IgE by human lymphocytes

Y. Levo, R. J. Harbeck, C. H. Kirkpatrick

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of different concentrations of hydrocortisone (HC) on the in vitro, pokeweed mitogen-driven synthesis of IgG and IgE by human lymphocytes was studied. HC had the same modulatory action on the production of both immunoglobulins. Two different effects were observed: the first is enhancement of Ig synthesis by low concentrations of HC (10-7-10-4 M), and the second is inhibition of synthesis by higher concentrations due to lymphocytoxic effect.

Original languageEnglish
Pages (from-to)413-415
Number of pages3
JournalInternational Archives of Allergy and Applied Immunology
Volume77
Issue number4
DOIs
StatePublished - 1985
Externally publishedYes

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