The effect of different concentrations of hydrocortisone (HC) on the in vitro, pokeweed mitogen-driven synthesis of IgG and IgE by human lymphocytes was studied. HC had the same modulatory action on the production of both immunoglobulins. Two different effects were observed: the first is enhancement of Ig synthesis by low concentrations of HC (10-7-10-4 M), and the second is inhibition of synthesis by higher concentrations due to lymphocytoxic effect.
|Number of pages||3|
|Journal||International Archives of Allergy and Applied Immunology|
|State||Published - 1985|