TY - JOUR
T1 - Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals
AU - Ramasamy, Saravana K.
AU - Kusumbe, Anjali P.
AU - Itkin, Tomer
AU - Gur-Cohen, Shiri
AU - Lapidot, Tsvee
AU - Adams, Ralf H.
N1 - Publisher Copyright:
© 2016 by Annual Reviews. All rights reserved.
PY - 2016/10/6
Y1 - 2016/10/6
N2 - In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
AB - In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
KW - Angiocrine factors
KW - Bone angiogenesis
KW - Hematopoietic stem cells
KW - Vascular niche
UR - http://www.scopus.com/inward/record.url?scp=84990837160&partnerID=8YFLogxK
U2 - 10.1146/annurev-cellbio-111315-124936
DO - 10.1146/annurev-cellbio-111315-124936
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 27576121
AN - SCOPUS:84990837160
SN - 1081-0706
VL - 32
SP - 649
EP - 675
JO - Annual Review of Cell and Developmental Biology
JF - Annual Review of Cell and Developmental Biology
ER -