Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals

Saravana K. Ramasamy, Anjali P. Kusumbe, Tomer Itkin, Shiri Gur-Cohen, Tsvee Lapidot, Ralf H. Adams

Research output: Contribution to journalReview articlepeer-review


In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.

Original languageEnglish
Pages (from-to)649-675
Number of pages27
JournalAnnual Review of Cell and Developmental Biology
StatePublished - 6 Oct 2016
Externally publishedYes


  • Angiocrine factors
  • Bone angiogenesis
  • Hematopoietic stem cells
  • Vascular niche


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