Regulation of adult bone turnover by sex steroids

Baruch Frenkel*, Albert Hong, Sanjeev K. Baniwal, Gerhard A. Coetzee, Claes Ohlsson, Omar Khalid, Yankel Gabet

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Recent reports reveal increasing complexity of mechanisms underlying the bone sparing effects of sex steroids. This review focuses on mechanisms by which sex steroids attenuate endocortical and trabecular adult bone turnover, perhaps their most important property as bone mass regulators. Clearly, estrogen withdrawal increases osteoclast number and bone resorption; however, important open questions are the extent to which osteoblasts and their precursors are involved, and the relative contributions of the RANK/RANKL/ OPG system, Fas ligand and Runx2. In addition to reviewing these aspects of estrogen action, we also discuss proskeletal effects of androgens on the adult male skeleton, including aromatization to estrogens and male-specific mechanisms. Detailed understanding of skeletal site- and gender-dependent mechanisms by which sex steroids protect the adult skeleton will provide the foundation for improved risk assessment, prevention and management of osteoporosis.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalJournal of Cellular Physiology
Issue number2
StatePublished - Aug 2010
Externally publishedYes


FundersFunder number
Seventh Framework Programme201865


    Dive into the research topics of 'Regulation of adult bone turnover by sex steroids'. Together they form a unique fingerprint.

    Cite this