Regulation of adenosine receptors in cultured heart cells

D. El-Ani*, K. A. Jacobson, A. Shainberg, J. Solaro, H. E.D.J. Ter Keurs, W. Barry, G. Kessler-Icekson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A1 adenosine receptors were studied on heart cells grown in cultures by the radioligand binding technique. Treatments with agents that accelerated heart rate for 3-4 days, caused an increase in the level of adenosine receptors. Treatments that attenuated heart rate, reduced the level of the receptors. Thus, the cardiac cells respond to environmental conditions affecting heart contraction so as to restore the basal rate of heart activity.

Original languageEnglish
Pages (from-to)205-215
Number of pages11
JournalAdvances in Experimental Medicine and Biology
StatePublished - 1995
Externally publishedYes


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