Regulation and organization of the groE and dnaK operons in Eubacteria

Gil Segal, Eliora Z. Ron*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

135 Scopus citations


groEL and dnaK are the most highly conserved protein-coding genes known. Most groEL operons and several dnaK and dnaJ operons contain a highly conserved inverted repeat (IR) sequence in their regulatory region. So far, this IR has been found only as part of the groE, dnaK and dnaJ operons and genes. In most cases, the IR is part of the operon transcript, and is involved in the regulation of expression at both the DNA and the mRNA levels. A detailed analysis of groE and dnaK operons indicates that the organization of the groE operons is highly conserved. They contain only the groES and groEL genes and always in the same order. In contrast, the organization of the dnaK operons has changed during evolution: genes have been added and deleted from it, and the gene order within the operon is variable.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalFEMS Microbiology Letters
Issue number1
StatePublished - 15 Apr 1996


FundersFunder number
Israel Science Foundation


    • Chaperon
    • Heat shock
    • Hsp60
    • Hsp70
    • dnaK
    • groE
    • grpE


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