@inbook{4d187f9ef2a2463e93429f04108c5ba3,
title = "Regulation and Function of Adiponectin Receptors in Skeletal Muscle",
abstract = "Obesity-induced insulin resistance is a primary contributing factor in the pathogenesis of type 2 diabetes. Adiponectin, an adipocyte-derived abundant plasma protein, has profound effects on systemic insulin sensitivity through direct action of the hormone on liver and muscle. The biological responses to adiponectin are mediated by two distinct receptors, AdipoR1 and AdipoR2, which differ in their affinities for adiponectin isoforms and exhibit cell type-specific effects. Disruption of AdipoR1 expression in muscle revealed a pivotal role of adiponectin/AdipoR1 in the regulation of mitochondrial biogenesis and insulin resistance. Here, we review the recent progress regarding adiponectin/AdipoRs signaling and function in skeletal muscle and summarize a range of physiological and pathophysiological conditions, as well as transcriptional and posttranscriptional mechanisms, controlling muscle AdipoR1 mRNA, and protein levels. Comprehensive understanding of the pathways that regulate AdipoRs expression in muscle is critical to benefit from the full therapeutic potential of the adiponectin-AdipoR system.",
keywords = "AdipoR1, AdipoR2, Adiponectin, Diabetes, Insulin resistance, Posttranscriptional regulation, Skeletal muscle, Transcriptional regulation",
author = "Yaniv Lustig and Rina Hemi and Hannah Kanety",
note = "Funding Information: Related work in the authors{\textquoteright} laboratory has been supported by the D-Cure Foundation for Diabetes Care in Israel and the Israel Association for the Study of Diabetes. Y. L. is supported by a postdoctoral fellowship from the International Human Frontier Science Program Organization. Unfortunately, it was not possible to quote all relevant literature, and we apologize for any omissions of pertinent research papers.",
year = "2012",
doi = "10.1016/B978-0-12-398313-8.00004-X",
language = "אנגלית",
series = "Vitamins and Hormones",
publisher = "Academic Press Inc.",
pages = "95--123",
booktitle = "Vitamins and Hormones",
address = "ארצות הברית",
}
