Regulating Higher-Order Organization through the Synergy of Two Self-Sorted Assemblies

Wei Ji, Shijin Zhang, Sachie Yukawa, Shogo Onomura, Toshio Sasaki, Kun'ichi Miyazawa, Ye Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The extracellular matrix (ECM) is the natural fibrous scaffold that regulates cell behavior in a hierarchical manner. By mimicking the dynamic and reciprocal interactions between ECM and cells, higher-order molecular self-assembly (SA), mediated through the dynamic growth of scaffold-like nanostructures assembled by different molecular components, was developed. Designed and synthesized were two self-sorted coumarin-based gelators, a peptide molecule and a benzoate molecule, which self-assemble into nanofibers and nanobelts, respectively, with different dynamic profiles. Upon the dynamic growth of the fibrous scaffold assembled from peptide gelators, nanobelts assembled from benzoate gelators transform into a layer-by-layer nanosheet, reaching ninefold increase in height. By using light and an enzyme, the spatial–temporal growth of the scaffold can be modified, leading to in situ height regulation of the higher-order architecture.

Original languageEnglish
Pages (from-to)3636-3640
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number14
StatePublished - 26 Mar 2018
Externally publishedYes


  • coumarin
  • gelators
  • higher-order organization
  • self-assembly
  • self-sorting


Dive into the research topics of 'Regulating Higher-Order Organization through the Synergy of Two Self-Sorted Assemblies'. Together they form a unique fingerprint.

Cite this