TY - JOUR
T1 - Regulated superinfection may help HIV adaptation on rugged landscape
AU - Leontiev, Vladimir
AU - Hadany, Lilach
N1 - Funding Information:
We wish to thank Tuvik Beker and Wendy J. Maury for many helpful comments. The research was supported in part by NSF grant 0639990 (L.H.) and by ISF grant 840/08 (L.H.).
PY - 2010/5
Y1 - 2010/5
N2 - Human immunodeficiency virus (HIV) is highly adaptable to a, changing environment, including host immune response and antiviral drugs. Superinfection occurs when several HIV proviruses share the same host cell. We previously proposed that HIV may regulate the rate of its superinfection, which would help the virus to adapt (Leontiev et al., 2008). In this paper we, investigate the effect of regulated superinfection in HIV on complex, adaptation on rugged fitness landscapes. We present the results of our in silico experiments that suggest that regulated superinfection facilitates HIV, adaptation on rugged fitness landscapes and that the advantage of regulated, superinfection increases with the ruggedness of the landscape.
AB - Human immunodeficiency virus (HIV) is highly adaptable to a, changing environment, including host immune response and antiviral drugs. Superinfection occurs when several HIV proviruses share the same host cell. We previously proposed that HIV may regulate the rate of its superinfection, which would help the virus to adapt (Leontiev et al., 2008). In this paper we, investigate the effect of regulated superinfection in HIV on complex, adaptation on rugged fitness landscapes. We present the results of our in silico experiments that suggest that regulated superinfection facilitates HIV, adaptation on rugged fitness landscapes and that the advantage of regulated, superinfection increases with the ruggedness of the landscape.
KW - Computational models
KW - HIV
KW - Phenotypic rescue
KW - Recombination
KW - Rugged fitness landscape
KW - Superinfection
UR - http://www.scopus.com/inward/record.url?scp=77951975884&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2010.02.010
DO - 10.1016/j.meegid.2010.02.010
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AN - SCOPUS:77951975884
SN - 1567-1348
VL - 10
SP - 505
EP - 510
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
IS - 4
ER -
