TY - JOUR
T1 - Regulated proteolysis in Gram-negative bacteria-how and when?
AU - Gur, Eyal
AU - Biran, Dvora
AU - Ron, Eliora Z.
N1 - Funding Information:
We thank the anonymous reviewers and the editor for their helpful suggestions. Work in the authors’ laboratory was supported by a DIP grant from the Deutsche Forschungsgemeinschaft (to E.Z.R. and D.B.), by a Marie Curie International Reintegration Grant (IRG) and by a German–Israeli Foundation (GIF) Young grant (to E.G.).
PY - 2011/12
Y1 - 2011/12
N2 - Most bacteria live in a dynamic environment where temperature, availability of nutrients and the presence of various chemicals vary, which requires rapid adaptation. Many of the adaptive changes are determined by changes in the transcription of global regulatory networks, but this response is slow because most bacterial proteins are stable and their concentration remains high even after transcription slows down. To respond rapidly, an additional level of regulation has evolved: the degradation of key proteins. However, as proteolysis is an irreversible process, it is subject to tight regulation of substrate binding and degradation. Here we review the roles of the proteolytic enzymes in Gram-negative bacteria and how these enzymes can be regulated to target only a subset of proteins.
AB - Most bacteria live in a dynamic environment where temperature, availability of nutrients and the presence of various chemicals vary, which requires rapid adaptation. Many of the adaptive changes are determined by changes in the transcription of global regulatory networks, but this response is slow because most bacterial proteins are stable and their concentration remains high even after transcription slows down. To respond rapidly, an additional level of regulation has evolved: the degradation of key proteins. However, as proteolysis is an irreversible process, it is subject to tight regulation of substrate binding and degradation. Here we review the roles of the proteolytic enzymes in Gram-negative bacteria and how these enzymes can be regulated to target only a subset of proteins.
UR - http://www.scopus.com/inward/record.url?scp=81255127216&partnerID=8YFLogxK
U2 - 10.1038/nrmicro2669
DO - 10.1038/nrmicro2669
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AN - SCOPUS:81255127216
SN - 1740-1526
VL - 9
SP - 839
EP - 848
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 12
ER -