Regioselective, one-pot syntheses of symmetrically and unsymmetrically halogenated 2',6'-bispyrazolylpyridines

Supratim Basak*, Pramiti Hui, Rajadurai Chandrasekar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A series of regio-selectively 3'-, 4-, 4'-, 4'-, and 5'-halogenated heterocyclic 2',6'-bispyrazolylpyridine derivatives was prepared by a direct halogenation reaction in a simple, one-pot synthesis in good to excellent yield (in gram scale). This methodology yielded several, symmetrically and asymmetrically substituted mono-, di-, tri-, and tetra-halo (bromo and iodo) substituted 2',6'bispyrazolylpyridine cores, which may serve as potential intermediates for several metal-catalyzed coupling reactions.

Original languageEnglish
Article numberT09109SS
Pages (from-to)4042-4048
Number of pages7
Issue number23
StatePublished - 2009
Externally publishedYes


  • 6-bis(pyrazol-l-yl)pyridine
  • Halogenated 2
  • Halogenation
  • Heterocycles
  • N-ligands
  • Pyridines


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