Regional variations of skin blood flow response to histamine: evaluation by spectrophotometry and laser Doppler flowmetry

E. Tur, G. Aviram, D. Zeltser, S. Brenner, Howard I. Maibach

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

To study inherent differences in skin function related to regional variation, we tested the hypothesis that different reactivities of small blood vessels via their direct and indirect activation by histamine play an important role in the observed regional variation of processes. Histamine was administered to three cutaneous regions in 20 volunteers, and the induced response was quantified utilizing spectrophotometry and laser Doppler flowmetry. The back exhibited the greatest response, followed by the forearm and ankle in decreasing order of responsiveness. We suggest that the intensity of the wheal and flare response may partly be related to the local reactivity of the blood vessels once the histamine actually reached them, and to their indirect dilatation via the axonal reflex. These blood vessel response observations may provide initial insight into inherent functional differences influencing cutaneous manifestations of endogenous and exogenous diseases.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsStephen G. Bown, Frederic Laffitte, Raimund Hibst, Hans-Dieter Reidenbach, Herbert J. Geschwind, al et al
Pages15-19
Number of pages5
StatePublished - 1996
Externally publishedYes
EventMedical Applications of Lasers III - Barcelona, Spain
Duration: 12 Sep 199516 Sep 1995

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2623
ISSN (Print)0277-786X

Conference

ConferenceMedical Applications of Lasers III
CityBarcelona, Spain
Period12/09/9516/09/95

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