TY - JOUR
T1 - Regional cerebral blood flow in parkinsonism. Measurement before and after levodopa
AU - Melamed, Eldad
AU - Lavy, Sylvan
AU - Cooper, Gerald
AU - Bentin, Shlomo
N1 - Funding Information:
Recently, there has been an increasing interest in the role of neurotransmitters in control and regulation of the regional cerebral blood flow (rCBF) and cerebral metabolism (Owman, Edvinsson and Nielsen 1974; Lavyne, Wurtman and Moskowitz 1975). Dopamine is an important central neurotransmitter and many studies have shown that in addition to dopaminergic projections to the caudate-putamen area, dopamine-containing nerve terminals are also present in the mammalian neocortex (Lindvall, Bjfrklund, Moore and Stenevi 1974; Berger, Thierry, Tassin and Moyne 1976; MacBrown and Goldman 1977). However, little and conflicting information is This study was supported in part by grant No. 572 from the Israel Ministry of Health, Chief Scientist's Office.
PY - 1978/10
Y1 - 1978/10
N2 - Data from recent studies in experimental animals suggest that central dopaminergic mechanisms may be involved in regulation of the regional cerebral blood flow (rCBF) in the mammalian brain. In order to evaluate possible effects of dopaminergic stimulation on human cerebral circulation, rCBF was measured by the 133Xenon inhalation technique in 26 patients with Parkinson's disease before and after the chronic oral administration of levodopa combined with a peripheral Dopa-decarboxylase inhibitor. Treatment with levodopa did not induce significant alterations in the mean brain, mean hemispheric or regional flow values in these patients. These findings suggest that the dopaminergic system does not play an important role in modulation of the rCBF in man.
AB - Data from recent studies in experimental animals suggest that central dopaminergic mechanisms may be involved in regulation of the regional cerebral blood flow (rCBF) in the mammalian brain. In order to evaluate possible effects of dopaminergic stimulation on human cerebral circulation, rCBF was measured by the 133Xenon inhalation technique in 26 patients with Parkinson's disease before and after the chronic oral administration of levodopa combined with a peripheral Dopa-decarboxylase inhibitor. Treatment with levodopa did not induce significant alterations in the mean brain, mean hemispheric or regional flow values in these patients. These findings suggest that the dopaminergic system does not play an important role in modulation of the rCBF in man.
UR - http://www.scopus.com/inward/record.url?scp=0018170686&partnerID=8YFLogxK
U2 - 10.1016/0022-510X(78)90144-2
DO - 10.1016/0022-510X(78)90144-2
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AN - SCOPUS:0018170686
VL - 38
SP - 391
EP - 397
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 3
ER -
