Region-specific changes in brain diffusivity in fetal isolated mild ventriculomegaly

Gal Yaniv*, Eldad Katorza, Ronen Bercovitz, Dafi Bergman, Gahl Greenberg, Anat Biegon, Chen Hoffmann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: To evaluate the impact of symmetric and asymmetric isolated mild ventriculomegaly (IMVM, atrial width 10–15 mm) on apparent diffusion coefficient (ADC) values in fetal brain areas. Methods: Sixty-seven sequential fetal head magnetic resonance imaging scans (feMRI) of VM cases performed between 2009 and 2014 were compared to 38 normal feMRI scans matched for gestational age (controls). Ultrasound- and MRI-proven IMVM cases were divided into asymmetrical (AVM, ≥2 mm difference in atrial width), symmetrical (SVM, <2 mm difference in atrial width), and asymmetrical IMVM with one normal-sized ventricle (AV1norm). Results: ADC values were significantly elevated in the basal ganglia (BG) of the SVM and AV1norm groups compared to controls (p < 0.004 and p < 0.013, respectively). High diffusivity was constantly detected in the BG ipsilateral to the enlarged atria relative to the normal-sized atria in the AV1norm group (p < 0.03). Frontal lobe ADC values were significantly reduced in the AVM and SVM groups (p < 0.003 and p < 0.003 vs. controls). Temporal lobe ADC values were significantly reduced in the AVM group (p < 0.001 vs. controls). Conclusion: Isolated mild ventriculomegaly is associated with distinct ADC value changes in different brain regions. This phenomenon could reflect the pathophysiology associated with different IMVM patterns.

Original languageEnglish
Pages (from-to)840-848
Number of pages9
JournalEuropean Radiology
Issue number3
StatePublished - 1 Mar 2016
Externally publishedYes


  • ADC
  • Fetal MRI
  • Fetus
  • Ultrasound
  • Ventriculomegaly


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