Refractory disease in autoimmune diseases

Carlos Vasconcelos; Cees Kallenberg; Yehuda Shoenfeld

doi:10.1016/j.autrev.2011.04.026

Refractory disease in autoimmune diseases

Carlos Vasconcelos^*, Cees Kallenberg, Yehuda Shoenfeld

^*Corresponding author for this work

Research output: Contribution to journal › Editorial

5 Scopus citations

Abstract

Refractory disease (RD) definition has different meanings but it is dynamic, according to knowledge and the availability of new drugs. It should be differentiated from severe disease and damage definitions and it must take into account duration of adequate therapy and compliance of the patient. It can be related to inadequate or inefficacious treatment or to pathogenesis. RD definition has multiple implications to clinical guidelines and to the use of off-label drugs. It should not be regarded as lost cases and prospective studies, registries and clinical trials should be planned.

Original language	English
Pages (from-to)	653-654
Number of pages	2
Journal	Autoimmunity Reviews
Volume	10
Issue number	11
DOIs	https://doi.org/10.1016/j.autrev.2011.04.026
State	Published - Sep 2011
Externally published	Yes

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10.1016/j.autrev.2011.04.026

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Refractory disease in autoimmune diseases

Abstract

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