TY - JOUR
T1 - Reflectance confocal microscopy of pigmented basal cell carcinoma
AU - Chan Agero, Anna Liza
AU - Busam, Klaus J.
AU - Benvenuto-Andrade, Cristiane
AU - Scope, Alon
AU - Gill, Melissa
AU - Marghoob, Ashfaq A.
AU - González, Salvador
AU - Halpern, Allan C.
PY - 2006/4
Y1 - 2006/4
N2 - Background: Reflectance confocal microscopy (RCM) is a high-resolution imaging tool for in vivo noninvasive evaluation of skin lesions. Objective: We sought to describe the relevant RCM features for pigmented basal cell carcinoma (BCC). Methods: Pigmented skin lesions with a differential diagnosis of pigmented BCC were imaged using dermoscopy and RCM, followed by excision for histologic analysis. Results: RCM demonstrated aggregations of tightly packed cells with palisading, forming cordlike structures and nodules with irregular borders and variable brightness; these represented nests of pigmented basaloid tumor cells on histopathology, and blue-gray ovoid areas on dermoscopy. These tumor nests were associated with bright dendritic structures, identified histologically as either melanocytes or Langerhans cells, together with numerous bright oval to stellate-shaped structures with indistinct borders representing melanophages, and with highly refractile granules of melanin. Limitations: The pigmented BCCs imaged in this study were predominantly nodular; a different set or additional criteria may be necessary for detection of infiltrative and metatypical BCCs. Conclusion: RCM may permit in vivo diagnosis of pigmented BCC.
AB - Background: Reflectance confocal microscopy (RCM) is a high-resolution imaging tool for in vivo noninvasive evaluation of skin lesions. Objective: We sought to describe the relevant RCM features for pigmented basal cell carcinoma (BCC). Methods: Pigmented skin lesions with a differential diagnosis of pigmented BCC were imaged using dermoscopy and RCM, followed by excision for histologic analysis. Results: RCM demonstrated aggregations of tightly packed cells with palisading, forming cordlike structures and nodules with irregular borders and variable brightness; these represented nests of pigmented basaloid tumor cells on histopathology, and blue-gray ovoid areas on dermoscopy. These tumor nests were associated with bright dendritic structures, identified histologically as either melanocytes or Langerhans cells, together with numerous bright oval to stellate-shaped structures with indistinct borders representing melanophages, and with highly refractile granules of melanin. Limitations: The pigmented BCCs imaged in this study were predominantly nodular; a different set or additional criteria may be necessary for detection of infiltrative and metatypical BCCs. Conclusion: RCM may permit in vivo diagnosis of pigmented BCC.
UR - http://www.scopus.com/inward/record.url?scp=33645005250&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2005.11.1096
DO - 10.1016/j.jaad.2005.11.1096
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C2 - 16546585
AN - SCOPUS:33645005250
SN - 0190-9622
VL - 54
SP - 638
EP - 643
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -