Reflectance confocal microscopy may enhance the accuracy of histopathologic diagnosis: A case series

Neda Shahriari, Jane M. Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope

Research output: Contribution to journalArticlepeer-review

Abstract

Although histopathology is the time-honored gold standard diagnostic measure in dermatology, several factors may detract from an accurate microscopic diagnosis. Limiting factors include: human error, suboptimal biopsy-site selection or biopsy technique, and inherent restrictions of vertical tissue sectioning that lead to incomplete microscopic evaluation of the lesion. Reflectance confocal microscopy (RCM) is a non-invasive imaging tool that allows for the cellular-level examination of the lesion, at a horizontal plane, which may complement the subsequent vertical histopathological tissue examination. Herein, we report a case series whereby prebiopsy RCM examination enhanced the accuracy of histopathological diagnosis or allowed for a critical appraisal of initial histopathological misdiagnosis.

Original languageEnglish
Pages (from-to)830-838
Number of pages9
JournalJournal of Cutaneous Pathology
Volume46
Issue number11
DOIs
StatePublished - 1 Nov 2019

Keywords

  • basal cell carcinoma
  • confocal microscopy
  • histopathology
  • melanoma

Fingerprint

Dive into the research topics of 'Reflectance confocal microscopy may enhance the accuracy of histopathologic diagnosis: A case series'. Together they form a unique fingerprint.

Cite this