Reduction in serotonin 5HT2 receptor binding on platelets of delinquent adolescents

R. Blumensohn, G. Ratzoni, A. Weizman, A. Apter, S. Tyano, M. Israeli, N. Greuner, A. Biegon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The possible involvement of serotonin receptors of the 5HT2 type in aggressive behavior was studied in juvenile delinquents. A group of 28 delinquent adolescents (13-18 years old) who had committed violent crimes was compared with a group of age matched controls. Subjects were drug and medication free during the study. 5HT2 receptors were labeled on platelet membranes using tritiated ketanserin. Receptor binding in the delinquent adolescents was significantly lower than in age matched controls. Mean ± SD of 76 controls was 32.3±14.2 fm/mg, compared to 16.6±8.2 fm/mg in 28 delinquents (P<0.002, Student's t-test). These results support a role for serotonin in general and 5HT2 receptors in particular in human aggressive behavior.

Original languageEnglish
Pages (from-to)354-356
Number of pages3
Issue number3
StatePublished - Apr 1995
Externally publishedYes


  • Aggression
  • Peripheral serotonin receptors


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