Reduction in regional cerebral blood flow during normal aging in man

Eldad Melamed; Sylvan Lavy; Shlomo Bentin; Gerald Cooper; Yosef Rinot

doi:10.1161/01.STR.11.1.31

Reduction in regional cerebral blood flow during normal aging in man

Eldad Melamed, Sylvan Lavy, Shlomo Bentin, Gerald Cooper, Yosef Rinot

Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

241 Scopus citations

Abstract

Regional cerebral blood flow (rCBF) was measured by the ¹³³Xenon inhalation method in a selected group of 44 normal non-hospitalized, normotensive subjects aged 19 to 79 years. rCBF was computed as the initial slope index value (ISI). Advancing age was associated with significant reductions in the mean brain and mean hemispheric ISI as well as in individual ISI levels measured from all areas in both hemispheres. Our findings suggest that decline of rCBF is not limited to normal elderly subjects but that it is a progressive phenomenon which begins at an earlier age.

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Stroke
Volume	11
Issue number	1
DOIs	https://doi.org/10.1161/01.STR.11.1.31
State	Published - 1980
Externally published	Yes

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AU - Melamed, Eldad

AU - Lavy, Sylvan

AU - Bentin, Shlomo

AU - Cooper, Gerald

AU - Rinot, Yosef

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AB - Regional cerebral blood flow (rCBF) was measured by the 133Xenon inhalation method in a selected group of 44 normal non-hospitalized, normotensive subjects aged 19 to 79 years. rCBF was computed as the initial slope index value (ISI). Advancing age was associated with significant reductions in the mean brain and mean hemispheric ISI as well as in individual ISI levels measured from all areas in both hemispheres. Our findings suggest that decline of rCBF is not limited to normal elderly subjects but that it is a progressive phenomenon which begins at an earlier age.

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Reduction in regional cerebral blood flow during normal aging in man

Abstract

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