TY - JOUR
T1 - Reduction in formation of peritoneal adhesions by methylene blue in rats
T2 - A dose response study
AU - Kluger, Yoram
AU - Weinbroum, Avi
AU - Ben-Avraham, Ron
AU - Galili, Yair
AU - Klausner, Joseph
AU - Rabau, Micha
PY - 2000
Y1 - 2000
N2 - Objective: To find out if the ability of methylene blue given intraperitoneally to reduce surgically-induced adhesions in rats is concentration dependent. Design: Random, controlled prospective study. Setting: Teaching hospital, Israel. Animals: Seventy female Wistar rats. Interventions: Intraperitoneal adhesions were generated in rats by scraping the anterior wall of the uterine horn. They were then given either saline or serially diluted methylene blue intraperitoneally. Additional rats received identical treatments, but without the serosal damage. Outcome measures: Graded formation of adhesions, two weeks later. Results: In the rats treated with methylene blue 1%, adhesion formation was similar to that in sham operated rats and was significantly lower (p < 0.001) than in all other groups. Conclusion: Methylene blue 1%, and to lesser degree 0.5%, had the best anti-adhesion potential. Lower methylene blue concentrations were only partially effective, and much high concentrations may cause adverse effects.
AB - Objective: To find out if the ability of methylene blue given intraperitoneally to reduce surgically-induced adhesions in rats is concentration dependent. Design: Random, controlled prospective study. Setting: Teaching hospital, Israel. Animals: Seventy female Wistar rats. Interventions: Intraperitoneal adhesions were generated in rats by scraping the anterior wall of the uterine horn. They were then given either saline or serially diluted methylene blue intraperitoneally. Additional rats received identical treatments, but without the serosal damage. Outcome measures: Graded formation of adhesions, two weeks later. Results: In the rats treated with methylene blue 1%, adhesion formation was similar to that in sham operated rats and was significantly lower (p < 0.001) than in all other groups. Conclusion: Methylene blue 1%, and to lesser degree 0.5%, had the best anti-adhesion potential. Lower methylene blue concentrations were only partially effective, and much high concentrations may cause adverse effects.
KW - Abdominal surgery
KW - Adhesions
KW - Methylene blue
UR - http://www.scopus.com/inward/record.url?scp=0033930482&partnerID=8YFLogxK
U2 - 10.1080/110241500750008655
DO - 10.1080/110241500750008655
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AN - SCOPUS:0033930482
SN - 1102-4151
VL - 166
SP - 568
EP - 571
JO - British Journal of Surgery
JF - British Journal of Surgery
IS - 7
ER -