Reduced virulence of Candida albicans mutants affected in multidrug resistance

J. M. Becker; L. K. Henry; W. Jiang; Y. Koltin

doi:10.1128/iai.63.11.4515-4518.1995

Reduced virulence of Candida albicans mutants affected in multidrug resistance

J. M. Becker^*, L. K. Henry, W. Jiang, Y. Koltin

^*Corresponding author for this work

University of Tennessee, Knoxville

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Disruption of a multidrug resistance gene (CaMDR1) in Candida albicans resulted in mutant strains that colonized mouse kidneys to very high levels but were markedly reduced in their virulence. No obvious differences in several properties related to colonization and dissemination were noted among MDR⁺ or mdr^- strains. These results suggest that specific fungal efflux pumps play a role in fungal pathogenicity.

Original language	English
Pages (from-to)	4515-4518
Number of pages	4
Journal	Infection and Immunity
Volume	63
Issue number	11
DOIs	https://doi.org/10.1128/iai.63.11.4515-4518.1995
State	Published - 1995
Externally published	Yes

Funding

Funders	Funder number
National Institute of Allergy and Infectious Diseases	U01AI035262

Access to Document

10.1128/iai.63.11.4515-4518.1995

Cite this

@article{413420427f6c4d7fb16e455c44bc163b,

title = "Reduced virulence of Candida albicans mutants affected in multidrug resistance",

abstract = "Disruption of a multidrug resistance gene (CaMDR1) in Candida albicans resulted in mutant strains that colonized mouse kidneys to very high levels but were markedly reduced in their virulence. No obvious differences in several properties related to colonization and dissemination were noted among MDR+ or mdr- strains. These results suggest that specific fungal efflux pumps play a role in fungal pathogenicity.",

author = "Becker, {J. M.} and Henry, {L. K.} and W. Jiang and Y. Koltin",

year = "1995",

doi = "10.1128/iai.63.11.4515-4518.1995",

language = "אנגלית",

volume = "63",

pages = "4515--4518",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "11",

}

TY - JOUR

T1 - Reduced virulence of Candida albicans mutants affected in multidrug resistance

AU - Becker, J. M.

AU - Henry, L. K.

AU - Jiang, W.

AU - Koltin, Y.

PY - 1995

Y1 - 1995

N2 - Disruption of a multidrug resistance gene (CaMDR1) in Candida albicans resulted in mutant strains that colonized mouse kidneys to very high levels but were markedly reduced in their virulence. No obvious differences in several properties related to colonization and dissemination were noted among MDR+ or mdr- strains. These results suggest that specific fungal efflux pumps play a role in fungal pathogenicity.

AB - Disruption of a multidrug resistance gene (CaMDR1) in Candida albicans resulted in mutant strains that colonized mouse kidneys to very high levels but were markedly reduced in their virulence. No obvious differences in several properties related to colonization and dissemination were noted among MDR+ or mdr- strains. These results suggest that specific fungal efflux pumps play a role in fungal pathogenicity.

UR - http://www.scopus.com/inward/record.url?scp=0028844181&partnerID=8YFLogxK

U2 - 10.1128/iai.63.11.4515-4518.1995

DO - 10.1128/iai.63.11.4515-4518.1995

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0028844181

SN - 0019-9567

VL - 63

SP - 4515

EP - 4518

JO - Infection and Immunity

JF - Infection and Immunity

IS - 11

ER -

Reduced virulence of Candida albicans mutants affected in multidrug resistance

Abstract

Funding

Access to Document

Other files and links

Fingerprint

Cite this