TY - JOUR
T1 - Reduced suprathreshold odor identification in patients with pseudotumor cerebri
T2 - A non-randomized prospective study
AU - Dotan, Gad
AU - Cohen, Eyal
AU - Klein, Ainat
AU - Kesler, Anat
N1 - Publisher Copyright:
© 2018, Israel Medical Association. All rights reserved.
PY - 2018/1
Y1 - 2018/1
N2 - Background: Recent evidence suggests that olfaction is impaired in patients with pseudotumor cerebri (PTC). Objectives: To measure suprathreshold olfactory function by using the University of Pennsylvania Smell Identification Test (UPSIT), assessing its usefulness for routine clinical use. Methods: Forty PTC patients underwent USPIT olfactory testing. Results: Twenty-nine out of 40 (73%) PTC patients (36 women, 4 men; mean age 34 years) had reduced suprathreshold smell sensation according to UPSIT scores: 19 (47%) had mild microsmia, 9 (23%) had moderate microsmia, and one (3%) was classified as having severe microsmia. The mean UPSIT score of all patients was 32.4 (95% confidence interval 31.4–33.4). Multivariate regression analysis found that UPSIT scores were not related to disease activity, disease duration, initial intracranial pressure (ICP), or visual function. Conclusions: Many PTC patients have reduced suprathreshold olfactory dysfunction that can be discovered by UPSIT, a rapidly administered smell test, which is suitable for clinical office use.
AB - Background: Recent evidence suggests that olfaction is impaired in patients with pseudotumor cerebri (PTC). Objectives: To measure suprathreshold olfactory function by using the University of Pennsylvania Smell Identification Test (UPSIT), assessing its usefulness for routine clinical use. Methods: Forty PTC patients underwent USPIT olfactory testing. Results: Twenty-nine out of 40 (73%) PTC patients (36 women, 4 men; mean age 34 years) had reduced suprathreshold smell sensation according to UPSIT scores: 19 (47%) had mild microsmia, 9 (23%) had moderate microsmia, and one (3%) was classified as having severe microsmia. The mean UPSIT score of all patients was 32.4 (95% confidence interval 31.4–33.4). Multivariate regression analysis found that UPSIT scores were not related to disease activity, disease duration, initial intracranial pressure (ICP), or visual function. Conclusions: Many PTC patients have reduced suprathreshold olfactory dysfunction that can be discovered by UPSIT, a rapidly administered smell test, which is suitable for clinical office use.
KW - Hyposmia
KW - Idiopathic intracranial hypertension (IIH)
KW - Olfaction dysfunction
KW - Pseudotumor cerebri (PTC)
KW - Smelling dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85041713405&partnerID=8YFLogxK
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C2 - 29658205
AN - SCOPUS:85041713405
SN - 1565-1088
VL - 20
SP - 34
EP - 37
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 1
ER -