Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

Peer Dar; Dvora Strassburger; Aviv Shaish; Hannah Levkovitz; Reuvit Halperin; Dror Harats

doi:10.1159/000052934

Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

Peer Dar^*, Dvora Strassburger, Aviv Shaish, Hannah Levkovitz, Reuvit Halperin, Dror Harats

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R^-/-) and reproduction was compared to LDL-R^-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R^-/- mice as compared to the LDL-R^-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R^-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.

Original language	English
Pages (from-to)	18-21
Number of pages	4
Journal	Gynecologic and Obstetric Investigation
Volume	52
Issue number	1
DOIs	https://doi.org/10.1159/000052934
State	Published - 2001

Keywords

15-Lipoxygenase
Oxidized LDL
Reproduction
Spontaneous abortions
Transgenic mice

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10.1159/000052934

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title = "Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase",

abstract = "15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.",

keywords = "15-Lipoxygenase, Oxidized LDL, Reproduction, Spontaneous abortions, Transgenic mice",

author = "Peer Dar and Dvora Strassburger and Aviv Shaish and Hannah Levkovitz and Reuvit Halperin and Dror Harats",

year = "2001",

doi = "10.1159/000052934",

language = "אנגלית",

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journal = "Gynecologic and Obstetric Investigation",

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T1 - Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

AU - Dar, Peer

AU - Strassburger, Dvora

AU - Shaish, Aviv

AU - Levkovitz, Hannah

AU - Halperin, Reuvit

AU - Harats, Dror

PY - 2001

Y1 - 2001

N2 - 15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.

AB - 15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.

KW - 15-Lipoxygenase

KW - Oxidized LDL

KW - Reproduction

KW - Spontaneous abortions

KW - Transgenic mice

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JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

IS - 1

ER -

Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

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Keywords

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