TY - JOUR
T1 - Reduced pseudocholinesterase activity in patients with HELLP syndrome
AU - Lurie, Samuel
AU - Sadan, Oscar
AU - Oron, Galia
AU - Fux, Asora
AU - Boaz, Mona
AU - Ezri, Tiberiu
AU - Golan, Abraham
AU - Bar, Jacob
PY - 2007/2
Y1 - 2007/2
N2 - The authors previously reported a case of decreased pseudocholinesterase activity in a patient with HELLP syndrome. It was assumed that the reduced pseudocholinesterase activity in HELLP syndrome is associated with impaired liver function. The present study assesses the prevalence of low pseudocholinesterase in patients with HELLP syndrome. Serum pseudocholinesterase activity was determined with spectrophotometer in 15 patients with HELLP syndrome. Two control groups matched for gestational age were recruited: 15 healthy women with uncomplicated pregnancy and 15 women with severe preeclampsia without HELLP. The prevalence of reduced pseudocholinesterase activity lower than normal limit was 60.0% (9/15) in patients with HELLP syndrome, 33.3% (5/15) in patients with severe preeclampsia, and 6.6% (1/15) in women with normal pregnancy, respectively (P =.009). The pseudocholinesterase activity was found to correlate with serum alanine aminotransferase levels (r = 0.417, P =.006) and with serum aspartate aminotransferase levels (r = 0.462, P =.002). Considering the increased prevalence of reduced pseudocholinesterase activity in patients with HELLP syndrome, the authors suggest that whenever general anesthesia is applied in these patients, the anesthesiologist should be aware that the patient may show slow metabolic degradation of choline-ester drugs.
AB - The authors previously reported a case of decreased pseudocholinesterase activity in a patient with HELLP syndrome. It was assumed that the reduced pseudocholinesterase activity in HELLP syndrome is associated with impaired liver function. The present study assesses the prevalence of low pseudocholinesterase in patients with HELLP syndrome. Serum pseudocholinesterase activity was determined with spectrophotometer in 15 patients with HELLP syndrome. Two control groups matched for gestational age were recruited: 15 healthy women with uncomplicated pregnancy and 15 women with severe preeclampsia without HELLP. The prevalence of reduced pseudocholinesterase activity lower than normal limit was 60.0% (9/15) in patients with HELLP syndrome, 33.3% (5/15) in patients with severe preeclampsia, and 6.6% (1/15) in women with normal pregnancy, respectively (P =.009). The pseudocholinesterase activity was found to correlate with serum alanine aminotransferase levels (r = 0.417, P =.006) and with serum aspartate aminotransferase levels (r = 0.462, P =.002). Considering the increased prevalence of reduced pseudocholinesterase activity in patients with HELLP syndrome, the authors suggest that whenever general anesthesia is applied in these patients, the anesthesiologist should be aware that the patient may show slow metabolic degradation of choline-ester drugs.
KW - HELLP syndrome
KW - Obstetric anesthesia
KW - Pseudocholinesterase
KW - Severe preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=34648840400&partnerID=8YFLogxK
U2 - 10.1177/1933719107299871
DO - 10.1177/1933719107299871
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AN - SCOPUS:34648840400
SN - 1933-7191
VL - 14
SP - 192
EP - 196
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 2
ER -