Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections

Sivan Berger-Achituv*, Ronit Elhasid

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Data on the production of neutrophil extracellular traps (NETs) in leukemia patients are scant. Phagocytosis, hydrogen peroxide, neutrophil elastase and myeloperoxidase enzymatic activity as well as NETs formation were studied in 10 pediatric acute lymphoblastic leukemia and 7 pediatric acute myeloid leukemia (AML) patients after induction chemotherapy. Median neutrophil elastase activity and NETs formation were lower in AML versus acute lymphoblastic leukemia (41% vs. 90%, P=0.005 and 51% vs. 94%, P=0.008, respectively). AML patients had more episodes of febrile neutropenia during the first 2 blocks of treatment (100% vs. 40%, P=0.011) and a trend for more invasive bacterial and fungal infections.

Original languageEnglish
Pages (from-to)e248-e252
JournalJournal of Pediatric Hematology/Oncology
Volume40
Issue number4
DOIs
StatePublished - 2018

Keywords

  • acute lymphoblastic leukemia
  • acute myeloid leukemia
  • children
  • hydrogen peroxide
  • infections
  • myeloperoxidase
  • neutrophil elastase
  • neutrophil extracellular traps
  • phagocytosis

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