Reduced metabolites of 18-hydroxy-11-deoxycorticosterone

M. Harnik; Y. Aharonowittz; R. Lamed

doi:10.1016/0040-4020(82)80055-0

Reduced metabolites of 18-hydroxy-11-deoxycorticosterone

M. Harnik^*, Y. Aharonowittz, R. Lamed

^*Corresponding author for this work

Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Conditions are described for the preparation of the dihydro (2 and 6) and tetrahydro derivatives (3, 5 and 7) of 18-hydroxy-11-deoxycortisterone (1a) by microbial transformations using Clostridium parapurificum and chemical methods. The products were fully characterized and degraded into their respective 20 → 18 etiolactones. Microbial and chemical reductions of the Δ⁴-3-ketolactone 8 are presented.

Original language	English
Pages (from-to)	3173-3178
Number of pages	6
Journal	Tetrahedron
Volume	38
Issue number	21
DOIs	https://doi.org/10.1016/0040-4020(82)80055-0
State	Published - 1982

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10.1016/0040-4020(82)80055-0

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abstract = "Conditions are described for the preparation of the dihydro (2 and 6) and tetrahydro derivatives (3, 5 and 7) of 18-hydroxy-11-deoxycortisterone (1a) by microbial transformations using Clostridium parapurificum and chemical methods. The products were fully characterized and degraded into their respective 20 → 18 etiolactones. Microbial and chemical reductions of the Δ4-3-ketolactone 8 are presented.",

author = "M. Harnik and Y. Aharonowittz and R. Lamed",

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doi = "10.1016/0040-4020(82)80055-0",

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AU - Aharonowittz, Y.

AU - Lamed, R.

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N2 - Conditions are described for the preparation of the dihydro (2 and 6) and tetrahydro derivatives (3, 5 and 7) of 18-hydroxy-11-deoxycortisterone (1a) by microbial transformations using Clostridium parapurificum and chemical methods. The products were fully characterized and degraded into their respective 20 → 18 etiolactones. Microbial and chemical reductions of the Δ4-3-ketolactone 8 are presented.

AB - Conditions are described for the preparation of the dihydro (2 and 6) and tetrahydro derivatives (3, 5 and 7) of 18-hydroxy-11-deoxycortisterone (1a) by microbial transformations using Clostridium parapurificum and chemical methods. The products were fully characterized and degraded into their respective 20 → 18 etiolactones. Microbial and chemical reductions of the Δ4-3-ketolactone 8 are presented.

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Reduced metabolites of 18-hydroxy-11-deoxycorticosterone

Abstract

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