Reduced metabolites of 18-hydroxy-11-deoxycorticosterone

M. Harnik*, Y. Aharonowittz, R. Lamed

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Conditions are described for the preparation of the dihydro (2 and 6) and tetrahydro derivatives (3, 5 and 7) of 18-hydroxy-11-deoxycortisterone (1a) by microbial transformations using Clostridium parapurificum and chemical methods. The products were fully characterized and degraded into their respective 20 → 18 etiolactones. Microbial and chemical reductions of the Δ4-3-ketolactone 8 are presented.

Original languageEnglish
Pages (from-to)3173-3178
Number of pages6
Issue number21
StatePublished - 1982


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