TY - JOUR
T1 - Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia
T2 - A retrospective study from the European Group for Blood and Marrow Transplantation
AU - Mohty, Mohamad
AU - Labopin, Myriam
AU - Tabrizzi, Reza
AU - Theorin, Niklas
AU - Fauser, Axel A.
AU - Rambaldi, Alessandro
AU - Maertens, Johan
AU - Slavin, Shimon
AU - Majolino, Ignazio
AU - Nagler, Arnon
AU - Blaise, Didier
AU - Rocha, Vanderson
PY - 2008/2
Y1 - 2008/2
N2 - This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%; 42±10%; and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.
AB - This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%; 42±10%; and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.
KW - Acute lymphoblastic leukemia
KW - Allogeneic SCT
UR - http://www.scopus.com/inward/record.url?scp=40949131465&partnerID=8YFLogxK
U2 - 10.3324/haematol.11960
DO - 10.3324/haematol.11960
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C2 - 18245655
AN - SCOPUS:40949131465
SN - 0390-6078
VL - 93
SP - 303
EP - 306
JO - Haematologica
JF - Haematologica
IS - 2
ER -
