Reduced graft-versus-host reaction of T cells in kaposi’s sarcoma: A possible prognostic indicator

Michael David, Batya Shohat, Gregory Morozinski, Eleasar J. Feuerman

Research output: Contribution to journalArticlepeer-review

Abstract

In 20 patients with Kaposi’s sarcoma (KS) the level of B and T lymphocytes in the peripheral blood, as well as the function of T cells measured by the graft-versus-host reaction (GVHR), were investigated. Analysis of the results regarding the distribution of skin lesions showed that the mean GVHR was within normal range in 13 patients in whom the le-sions were confined to the distal portions of the extremities. In 7 patients, who demonstrated generalized distribution of the eruption, the mean GVHR was significantly lower in com-parison with the control group. In view of our results we may conclude that cellular immunity is impaired in KS patients with generalized distribution. Testing T cell function is re-commended as a possible prognostic indicator.

Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalDermatology
Volume169
Issue number2
DOIs
StatePublished - 1984

Keywords

  • Graft-versus-host reaction
  • Kaposi’s sarcoma
  • Prognostic indicator
  • T cell function

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