TY - JOUR
T1 - Reduced graft-versus-host reaction of T cells in kaposi’s sarcoma
T2 - A possible prognostic indicator
AU - David, Michael
AU - Shohat, Batya
AU - Morozinski, Gregory
AU - Feuerman, Eleasar J.
PY - 1984
Y1 - 1984
N2 - In 20 patients with Kaposi’s sarcoma (KS) the level of B and T lymphocytes in the peripheral blood, as well as the function of T cells measured by the graft-versus-host reaction (GVHR), were investigated. Analysis of the results regarding the distribution of skin lesions showed that the mean GVHR was within normal range in 13 patients in whom the le-sions were confined to the distal portions of the extremities. In 7 patients, who demonstrated generalized distribution of the eruption, the mean GVHR was significantly lower in com-parison with the control group. In view of our results we may conclude that cellular immunity is impaired in KS patients with generalized distribution. Testing T cell function is re-commended as a possible prognostic indicator.
AB - In 20 patients with Kaposi’s sarcoma (KS) the level of B and T lymphocytes in the peripheral blood, as well as the function of T cells measured by the graft-versus-host reaction (GVHR), were investigated. Analysis of the results regarding the distribution of skin lesions showed that the mean GVHR was within normal range in 13 patients in whom the le-sions were confined to the distal portions of the extremities. In 7 patients, who demonstrated generalized distribution of the eruption, the mean GVHR was significantly lower in com-parison with the control group. In view of our results we may conclude that cellular immunity is impaired in KS patients with generalized distribution. Testing T cell function is re-commended as a possible prognostic indicator.
KW - Graft-versus-host reaction
KW - Kaposi’s sarcoma
KW - Prognostic indicator
KW - T cell function
UR - http://www.scopus.com/inward/record.url?scp=0021239798&partnerID=8YFLogxK
U2 - 10.1159/000249572
DO - 10.1159/000249572
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AN - SCOPUS:0021239798
VL - 169
SP - 76
EP - 79
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 2
ER -