Reduced expression of activin a in focal lymphoid agglomerates within nasal polyps

T. Shoham, E. Yaniv, R. Koren, R. Gal, R. Parameswaran, A. Kravitz, H. Geron, D. Markovitz, M. Lantzki, D. Zipori

Research output: Contribution to journalArticlepeer-review

Abstract

It has been previously reported that activin A, a homodimer of the βA inhibin subunit, is secreted by stromal cells from mouse bone marrow and causes apoptotic death of mouse plasmacytoma tumor cells. Recent in vitro studies have also implicated this cytokine in the suppression of normal B-cell lymphopoiesis. In this study we examined the occurrence of activin A in nasal polyp tissues that present a combination of epithelium, mesenchyme, and vascular endothelium, with frequent massive hemopoietic infiltration. Anti-βA-chain antibodies strongly stained epithelial mucous glands and some endothelial cells, and diffusely stained the polyp stroma. Normal adult conchae were similarly stained, whereas activin A was not detected prenatally by immunostaining of nasal tissues. Staining specificity was substantiated by ligand competition assays. Detailed examination of the inflammatory polyp infiltrate showed that activin A staining was reduced in sites of focal infiltration of B-lymphoid cells. It is therefore implied that local accumulation of a large number of B-cells is associated with relatively low activin A expression.

Original languageEnglish
Pages (from-to)1245-1252
Number of pages8
JournalJournal of Histochemistry and Cytochemistry
Volume49
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Activin A
  • B-lymphocytes
  • Nasal polyps
  • Stroma
  • TGFβ

Fingerprint

Dive into the research topics of 'Reduced expression of activin a in focal lymphoid agglomerates within nasal polyps'. Together they form a unique fingerprint.

Cite this