Red eye syndrome: Clinical and experimental experience in a new aspect of diffuse eosinophilic infiltration?

Z. Averbukh, D. Modai, J. Sandbank, S. Berman, M. Cohn, E. Galperin, N. Cohen, V. Dishi, J. Weissgarten

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-two of 24 hemodialysis patients dialyzed simultaneously with a new batch of cellulose acetate dialyzers promptly developed a spectrum of symptoms and physical signs including red eyes, hearing loss, tinnitus, and bone pain, previously described as red eye syndrome. We subsequently injected 4 rabbits with an eluate from a dialyzer of the same or a control batch. Six hours following exposure, the animals developed, in addition to red eyes, diffuse eosinophilic infiltration of various organs as well as myopathic changes and moderate brain edema. On the basis of these data, we suggest that it cannot be concluded whether the underlying pathophysiological mechanisms were toxic, allergic or both and that the occurrence of relevant symptomatology in 2 or more simultaneously dialyzed patients is a strong argument against unnecessary diagnostic or therapeutic procedures. Finally, a second exposure in a given patient should be avoided.

Original languageEnglish
Pages (from-to)437-440
Number of pages4
JournalArtificial Organs
Volume25
Issue number6
DOIs
StatePublished - 2001

Keywords

  • Eosinophilia
  • Eosinophilic infiltration
  • Red eye syndrome
  • Uremia

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