Red blood cell antioxidant enzymes in rats after a single circadian-modulated delivery of 5-fluorouracil

N. Walach, S. Evans, O. Pinto, D. Cotariu

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied the status of the red blood cell antioxidant enzymes glutathione reductase (GR), glutathione peroxidase (GP), glutathione transferase (GT), superoxide dismutase (SOD) and catalase (CAT) in rats following a circadian-modulated delivery of the chemotherapeutic agent 5-fluorouracil (5-FU). There was a circadian variation in both GR and GT, with maximum activity during the dark/activity span. 5-FU significantly enhanced GR activity (P < 0.01) and lowered GT activity (P < 0.01); these effects were not dose-related and showed no circadian variability. GP, SOD and CAT activities were not subject to circadian variation. 5-FU had no effect on GP or SOD activity, but elicited a significant decline (P < 0.05 and 0.01, respectively) in CAT activity in the dark/activity span.

Original languageEnglish
Pages (from-to)571-572
Number of pages2
JournalMedical Science Research
Volume26
Issue number8
StatePublished - 1998
Externally publishedYes

Keywords

  • 5-fluorouracil
  • Antioxidant enzymes
  • Circadian-modulated delivery
  • Red blood cell

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