Recurrent Severe Infections Caused by a Novel Leukocyte Adhesion Deficiency

Amos Etzioni*, Moshe Frydman, Shimon Pollack, Israeli Avidor, M. Laurie Phillips, James C. Paulson, Ruth Gershoni-Baruch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


THE recruitment of neutrophils to sites of inflammation is initiated by the local production of bacteria-derived attractants, inflammatory cytokines, and other host-derived factors. These factors induce the rolling of neutrophils on the blood-vessel wall,1 2 3 4 followed by firm adhesion and extravasation into the surrounding infected or inflamed tissue.2 3 4 In recent years, there have been rapid advances in identifying the specific adhesion molecules that mediate the process of neutrophil recruitment.1 , 5 , 6 The initial rolling of neutrophils is mediated by members of the selectin family.2 , 4 , 7 , 8 These include E-selectin and P-selectin, which are expressed on the surface of activated endothelial cells, and L-selectin, which is…

Original languageEnglish
Pages (from-to)1789-1792
Number of pages4
JournalNew England Journal of Medicine
Issue number25
StatePublished - 17 Dec 1992


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