Recovery of visual response of injured adult rat optic nerves treated with transglutaminase

Shoshana Eitan; Arieh Solomon; Vered Lavie; Eti Yoles; David L. Hirschberg; Michael Belkin; Michal Schwartz

doi:10.1126/science.7911602

Recovery of visual response of injured adult rat optic nerves treated with transglutaminase

Shoshana Eitan, Arieh Solomon, Vered Lavie, Eti Yoles, David L. Hirschberg, Michael Belkin, Michal Schwartz^*

^*Corresponding author for this work

Eye Institute (Goldschleger)

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Failure of axons of the central nervous system in adult mammals to regenerate spontaneously after injury is attributed in part to inhibitory molecules associated with oligodendrocytes. Regeneration of central nervous system axons in fish is correlated with the presence of a transglutaminase. This enzyme dimerizes interleukin-2, and the product is cytotoxic to oligodendrocytes in vitro. Application of this nerve-derived transglutaminase to rat optic nerves, in which the injury had caused the loss of visual evoked potential response to light, promoted the recovery of that response within 6 weeks after injury. Transmission electron microscopy analysis revealed the concomitant appearance of axons in the distal stump of the optic nerve.

Original language	English
Pages (from-to)	1764-1768
Number of pages	5
Journal	Science
Volume	264
Issue number	5166
DOIs	https://doi.org/10.1126/science.7911602
State	Published - 1994

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abstract = "Failure of axons of the central nervous system in adult mammals to regenerate spontaneously after injury is attributed in part to inhibitory molecules associated with oligodendrocytes. Regeneration of central nervous system axons in fish is correlated with the presence of a transglutaminase. This enzyme dimerizes interleukin-2, and the product is cytotoxic to oligodendrocytes in vitro. Application of this nerve-derived transglutaminase to rat optic nerves, in which the injury had caused the loss of visual evoked potential response to light, promoted the recovery of that response within 6 weeks after injury. Transmission electron microscopy analysis revealed the concomitant appearance of axons in the distal stump of the optic nerve.",

author = "Shoshana Eitan and Arieh Solomon and Vered Lavie and Eti Yoles and Hirschberg, {David L.} and Michael Belkin and Michal Schwartz",

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AU - Belkin, Michael

AU - Schwartz, Michal

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Recovery of visual response of injured adult rat optic nerves treated with transglutaminase

Abstract

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