Reconstruction of genetic circuits

David Sprinzak, Michael B. Elowitz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

292 Scopus citations

Abstract

The complex genetic circuits found in cells are ordinarily studied by analysis of genetic and biochemical perturbations. The inherent modularity of biological components like genes and proteins enables a complementary approach: one can construct and analyse synthetic genetic circuits based on their natural counterparts. Such synthetic circuits can be used as simple in vivo models to explore the relation between the structure and function of a genetic circuit. Here we describe recent progress in this area of synthetic biology, highlighting newly developed genetic components and biological lessons learned from this approach.

Original languageEnglish
Pages (from-to)443-448
Number of pages6
JournalNature
Volume438
Issue number7067
DOIs
StatePublished - 24 Nov 2005
Externally publishedYes

Funding

FundersFunder number
Burroughs-Wellcome CASI
Yad Hanadiv Foundation
Horowitz Foundation for Social Policy
Searle Scholars Program

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