Reconstructing Denisovan Anatomy Using DNA Methylation Maps

David Gokhman; Nadav Mishol; Marc de Manuel; David de Juan; Jonathan Shuqrun; Eran Meshorer; Tomas Marques-Bonet; Yoel Rak; Liran Carmel

doi:10.1016/j.cell.2019.08.035

Reconstructing Denisovan Anatomy Using DNA Methylation Maps

David Gokhman^*, Nadav Mishol, Marc de Manuel, David de Juan, Jonathan Shuqrun, Eran Meshorer, Tomas Marques-Bonet, Yoel Rak, Liran Carmel

^*Corresponding author for this work

Anatomy and Anthropology

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

DNA methylation maps can be used to predict anatomical features in hominins and chimpanzees, allowing for reconstruction of a putative anatomical profile of the Denisovan, currently absent from the fossil record.

Original language	English
Pages (from-to)	180-192.e10
Journal	Cell
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.08.035
State	Published - 19 Sep 2019

Funding

Funders	Funder number
Clore Israel Foundation	BFU2017-86471-P
MINECO/FEDER	U01 MH106874
Shiran Bar
National Geographic Society	HJ-111R-17
Generalitat de Catalunya	GRC 2017 SGR 880

Keywords

Denisova
Neanderthal
aDNA
disease
jaw
loss of function
methylome
paleoepigenetics
paleogenomics
phenotype

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10.1016/j.cell.2019.08.035

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title = "Reconstructing Denisovan Anatomy Using DNA Methylation Maps",

abstract = "DNA methylation maps can be used to predict anatomical features in hominins and chimpanzees, allowing for reconstruction of a putative anatomical profile of the Denisovan, currently absent from the fossil record.",

keywords = "Denisova, Neanderthal, aDNA, disease, jaw, loss of function, methylome, paleoepigenetics, paleogenomics, phenotype",

author = "David Gokhman and Nadav Mishol and {de Manuel}, Marc and {de Juan}, David and Jonathan Shuqrun and Eran Meshorer and Tomas Marques-Bonet and Yoel Rak and Liran Carmel",

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T1 - Reconstructing Denisovan Anatomy Using DNA Methylation Maps

AU - Gokhman, David

AU - Mishol, Nadav

AU - de Manuel, Marc

AU - de Juan, David

AU - Shuqrun, Jonathan

AU - Meshorer, Eran

AU - Marques-Bonet, Tomas

AU - Rak, Yoel

AU - Carmel, Liran

PY - 2019/9/19

Y1 - 2019/9/19

N2 - DNA methylation maps can be used to predict anatomical features in hominins and chimpanzees, allowing for reconstruction of a putative anatomical profile of the Denisovan, currently absent from the fossil record.

AB - DNA methylation maps can be used to predict anatomical features in hominins and chimpanzees, allowing for reconstruction of a putative anatomical profile of the Denisovan, currently absent from the fossil record.

KW - Denisova

KW - Neanderthal

KW - aDNA

KW - disease

KW - jaw

KW - loss of function

KW - methylome

KW - paleoepigenetics

KW - paleogenomics

KW - phenotype

UR - http://www.scopus.com/inward/record.url?scp=85071987192&partnerID=8YFLogxK

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SN - 0092-8674

VL - 179

SP - 180-192.e10

JO - Cell

JF - Cell

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ER -

Reconstructing Denisovan Anatomy Using DNA Methylation Maps

Abstract

Funding

Keywords

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