Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe

Giulia Veronesi; David R. Baldwin; Claudia I. Henschke; Simone Ghislandi; Sergio Iavicoli; Matthijs Oudkerk; Harry J. De Koning; Joseph Shemesh; John K. Field; Javier J. Zulueta; Denis Horgan; Lucia Fiestas Navarrete; Maurizio Valentino Infante; Pierluigi Novellis; Rachael L. Murray; Nir Peled; Cristiano Rampinelli; Gaetano Rocco; Rzyman Witold; Giorgio Vittorio Scagliotti; Martin C. Tammemagi; Luca Bertolaccini; Natthaya Triphuridet; Rowena Yip; Alexia Rossi; Suresh Senan; Giuseppe Ferrante; Kate Brain; Carlijn van der Aalst; Lorenzo Bonomo; Dario Consonni; Jan P. Van Meerbeeck; Patrick Maisonneuve; Silvia Novello; Anand Devaraj; Zaigham Saghir; Giuseppe Pelosi

doi:10.3390/cancers12061672

Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe

Giulia Veronesi, David R. Baldwin, Claudia I. Henschke, Simone Ghislandi, Sergio Iavicoli, Matthijs Oudkerk, Harry J. De Koning, Joseph Shemesh, John K. Field, Javier J. Zulueta, Denis Horgan, Lucia Fiestas Navarrete, Maurizio Valentino Infante, Pierluigi Novellis, Rachael L. Murray, Nir Peled, Cristiano Rampinelli, Gaetano Rocco, Rzyman Witold, Giorgio Vittorio ScagliottiMartin C. Tammemagi, Luca Bertolaccini, Natthaya Triphuridet, Rowena Yip, Alexia Rossi, Suresh Senan, Giuseppe Ferrante, Kate Brain, Carlijn van der Aalst, Lorenzo Bonomo, Dario Consonni, Jan P. Van Meerbeeck, Patrick Maisonneuve, Silvia Novello, Anand Devaraj, Zaigham Saghir, Giuseppe Pelosi^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

Original language	English
Article number	1672
Pages (from-to)	1-24
Number of pages	24
Journal	Cancers
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/cancers12061672
State	Published - Jun 2020

Funding

Funders	Funder number
Royal Dutch Academy of Sciences
Varian Medical Systems
Horizon 2020 Framework Programme	848294
Horizon 2020 Framework Programme
ViewRay
ZonMw
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Associazione Italiana per la Ricerca sul Cancro

Keywords

Computed tomography
Consensus
Implementation
Low dose
Lung cancer
Mortality
Reduction
Screening
Statement

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cancers12061672

Cite this

Veronesi, G., Baldwin, D. R., Henschke, C. I., Ghislandi, S., Iavicoli, S., Oudkerk, M., De Koning, H. J., Shemesh, J., Field, J. K., Zulueta, J. J., Horgan, D., Navarrete, L. F., Infante, M. V., Novellis, P., Murray, R. L., Peled, N., Rampinelli, C., Rocco, G., Witold, R., ... Pelosi, G. (2020). Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe. Cancers, 12(6), 1-24. Article 1672. https://doi.org/10.3390/cancers12061672

@article{d79424d0157948cd9758308d06523f4a,

title = "Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe",

abstract = "Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.",

keywords = "Computed tomography, Consensus, Implementation, Low dose, Lung cancer, Mortality, Reduction, Screening, Statement",

author = "Giulia Veronesi and Baldwin, {David R.} and Henschke, {Claudia I.} and Simone Ghislandi and Sergio Iavicoli and Matthijs Oudkerk and {De Koning}, {Harry J.} and Joseph Shemesh and Field, {John K.} and Zulueta, {Javier J.} and Denis Horgan and Navarrete, {Lucia Fiestas} and Infante, {Maurizio Valentino} and Pierluigi Novellis and Murray, {Rachael L.} and Nir Peled and Cristiano Rampinelli and Gaetano Rocco and Rzyman Witold and Scagliotti, {Giorgio Vittorio} and Tammemagi, {Martin C.} and Luca Bertolaccini and Natthaya Triphuridet and Rowena Yip and Alexia Rossi and Suresh Senan and Giuseppe Ferrante and Kate Brain and {van der Aalst}, Carlijn and Lorenzo Bonomo and Dario Consonni and {Van Meerbeeck}, {Jan P.} and Patrick Maisonneuve and Silvia Novello and Anand Devaraj and Zaigham Saghir and Giuseppe Pelosi",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jun,

doi = "10.3390/cancers12061672",

language = "אנגלית",

volume = "12",

pages = "1--24",

journal = "Cancers",

issn = "2072-6694",

publisher = "MDPI Multidisciplinary Digital Publishing Institute",

number = "6",

}

Veronesi, G, Baldwin, DR, Henschke, CI, Ghislandi, S, Iavicoli, S, Oudkerk, M, De Koning, HJ, Shemesh, J, Field, JK, Zulueta, JJ, Horgan, D, Navarrete, LF, Infante, MV, Novellis, P, Murray, RL, Peled, N, Rampinelli, C, Rocco, G, Witold, R, Scagliotti, GV, Tammemagi, MC, Bertolaccini, L, Triphuridet, N, Yip, R, Rossi, A, Senan, S, Ferrante, G, Brain, K, van der Aalst, C, Bonomo, L, Consonni, D, Van Meerbeeck, JP, Maisonneuve, P, Novello, S, Devaraj, A, Saghir, Z & Pelosi, G 2020, 'Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe', Cancers, vol. 12, no. 6, 1672, pp. 1-24. https://doi.org/10.3390/cancers12061672

TY - JOUR

T1 - Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe

AU - Veronesi, Giulia

AU - Baldwin, David R.

AU - Henschke, Claudia I.

AU - Ghislandi, Simone

AU - Iavicoli, Sergio

AU - Oudkerk, Matthijs

AU - De Koning, Harry J.

AU - Shemesh, Joseph

AU - Field, John K.

AU - Zulueta, Javier J.

AU - Horgan, Denis

AU - Navarrete, Lucia Fiestas

AU - Infante, Maurizio Valentino

AU - Novellis, Pierluigi

AU - Murray, Rachael L.

AU - Peled, Nir

AU - Rampinelli, Cristiano

AU - Rocco, Gaetano

AU - Witold, Rzyman

AU - Scagliotti, Giorgio Vittorio

AU - Tammemagi, Martin C.

AU - Bertolaccini, Luca

AU - Triphuridet, Natthaya

AU - Yip, Rowena

AU - Rossi, Alexia

AU - Senan, Suresh

AU - Ferrante, Giuseppe

AU - Brain, Kate

AU - van der Aalst, Carlijn

AU - Bonomo, Lorenzo

AU - Consonni, Dario

AU - Van Meerbeeck, Jan P.

AU - Maisonneuve, Patrick

AU - Novello, Silvia

AU - Devaraj, Anand

AU - Saghir, Zaigham

AU - Pelosi, Giuseppe

PY - 2020/6

Y1 - 2020/6

N2 - Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

AB - Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

KW - Computed tomography

KW - Consensus

KW - Implementation

KW - Low dose

KW - Lung cancer

KW - Mortality

KW - Reduction

KW - Screening

KW - Statement

UR - http://www.scopus.com/inward/record.url?scp=85087083451&partnerID=8YFLogxK

U2 - 10.3390/cancers12061672

DO - 10.3390/cancers12061672

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 32599792

AN - SCOPUS:85087083451

SN - 2072-6694

VL - 12

SP - 1

EP - 24

JO - Cancers

JF - Cancers

IS - 6

M1 - 1672

ER -

Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe

Abstract

Funding

Keywords

UN SDGs

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