Recombinant human activin-a promotes proliferation of human luteinized preovulatory granulosa cells in vitro

Jaron Rabinovici, Susan J. Spencer, Robert B. Jaffe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Ovarian granulosa cells synthesize and secrete activin, a member of the transforming growth factor-beta (TGF-β) peptide family, during the follicular phase of the menstrual cycle. We examined the growth-promoting activity of human recombinant activin-A on human luteinized preovulatory granulosa cells obtained from women undergoing in vitro fertilization. Activin-A induced proliferation of granulosa cells on day 5 of culture in a dose-dependent manner. Maximal effects were seen at concentrations ≥ 100 ng/mL with an ED50 of 15 ng/mL. We suggest that activin-A is able to modulate growth of ovarian granulosa cells.

Original languageEnglish
Pages (from-to)1396-1398
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume71
Issue number5
StatePublished - Nov 1990
Externally publishedYes

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