Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

Je Hyun Baek, Moran Rubinstein, Todd Scheuer, James S. Trimmer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.

Original languageEnglish
Pages (from-to)15363-15373
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - 30 May 2014
Externally publishedYes

Funding

FundersFunder number
National Institutes of HealthR01 NS25704, R21 NS64428
National Institute of Neurological Disorders and StrokeR21NS064428

    Fingerprint

    Dive into the research topics of 'Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures'. Together they form a unique fingerprint.

    Cite this