Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients

Hoau Yan Wang, Eitan Friedman

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of Alzheimer's disease (AD) on [35S]GTPγS binding to G proteins was examined in postmortem cerebrocortex. Stimulation of the β-adrenergic or muscarinic cholinergic receptors in control tissue with selective agonists resulted in increases in [35S]GTPγS binding to Gα proteins in a receptor-specific fashion. The responses were markedly reduced in brain tissues from AD patients. In contrast, basal [35S]GTPγS binding to the Gα proteins was relatively intact in AD brains. Immunoblot analyses reveal that levels of cerebrocortical Gα proteins in AD are not altered. The results suggest that in AD the decrease in agonist-stimulated [35S]GTPγS binding to G proteins may be a result of decoupling between receptors and their associated G proteins.

Original languageEnglish
Pages (from-to)37-39
Number of pages3
JournalNeuroscience Letters
Volume173
Issue number1-2
DOIs
StatePublished - 23 May 1994
Externally publishedYes

Keywords

  • Alzheimer's disease
  • G protein
  • Immunoblot
  • Postmortem brain
  • [S]GTPγS binding

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