Recent advances in familial mediterranean fever

M. Pras, D. Zemer, Y. Shemer

Research output: Contribution to journalArticlepeer-review


Familial mediterranean fever is an hereditary disorder virtually restricted to Sephardi Jews, Armenians, Arabs of the Middle East and a few Ashkenazi Jews. It is characterized by brief febrile episodes of peritonitis, synovitis or pleuritis. Systemic amyloidosis develops in many of the patients and causes death at an early age. In 6% of the patients some synovial attacks assume a protracted form. Once the hip joint is affected by a prolonged attack, its function will be restricted to a marked degree. Amyloidosis is extremely common in Sephardi Jews while it is infrequent in Armenians and Ashkenazi Jews. Daily colchicine administration markedly decreases the frequency of febrile attacks as well as the development of amyloidosis.

Original languageEnglish
Pages (from-to)389-391
Number of pages3
JournalRhumatologie - Revue International de Rhumatologie
Issue number6
StatePublished - 1980
Externally publishedYes


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